Asian Journal of Neurosurgery

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 12  |  Issue : 1  |  Page : 22--27

First report of important causal relationship between the Adamkiewicz artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: An experimental study using a rabbit model


Osman N Turkmenoglu1, Ayhan Kanat2, Coskun Yolas3, Mehmet Dumlu Aydin4, Naci Ezirmik5, Cemal Gundogdu6 
1 Department of Neurosurgery, Sisli Etfal Research and Education Hospital, Istanbul, Turkey
2 Department of Neurosurgery, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey
3 Department of Neurosurgery, Numune Regional Research and Education Hospital, Erzurum, Turkey
4 Department of Neurosurgery, Ataturk University Medical Faculty, Erzurum, Turkey
5 Department of Orthopedic Surgery, Ataturk University Medical Faculty, Erzurum, Turkey
6 Department of Pathology, Ataturk University Medical Faculty, Erzurum, Turkey

Correspondence Address:
Mehmet Dumlu Aydin
Department of Neurosurgery, Medical Faculty, Recep Tayyip Erdogan University, Ekrem Orhon Mah. 2. Laleli Sok Yilmaz Apt 14/3 53100 Merkez-Rize
Turkey

Background: The blood supply of the lower spinal cord is heavily dependent on the artery of Adamkiewicz. The goal of this study was to elucidate the effects of lumbar subarachnoid hemorrhage (SAH) on the lumbar 4 dorsal root ganglion (L4DRG) cells secondary to Adamkiewicz artery (AKA) vasospasm. Materials and Methods: This study was conducted on 20 rabbits, which were randomly divided into three groups: Spinal SAH (n = 8), serum saline (SS) (SS; n = 6) and control (n = 6) groups. Experimental spinal SAH was performed. After 20 days, volume values of AKA and neuron density of L4DRG were analyzed. Results: The mean alive neuron density of the L4DRG was 15420 ± 1240/mm3 and degenerated neuron density was 1045 ± 260/mm3 in the control group. Whereas, the density of living and degenerated neurons density were 12930 ± 1060/mm3 and 1365 ± 480/mm3 in serum saline (SS), 9845 ± 1028/mm3 and 4560 ± 1340/mm3 in the SAH group. The mean volume of imaginary AKAs was estimated as 1,250 ± 0,310 mm3 in the control group and 1,030 ± 0,240 mm3 in the SF group and 0,910 ± 0,170 mm3 in SAH group. Volume reduction of the AKAs and neuron density L4DRG were significantly different between the SAH and other two groups (P < 0.05). Conclusion: Decreased volume of the lumen of the artery of Adamkiewicz was observed in animals with SAH compared with controls. Increased degeneration the L4 dorsal root ganglion in animals with SAH was also noted. Our findings will aid in the planning of future experimental studies and determining the clinical relevance on such studies.


How to cite this article:
Turkmenoglu ON, Kanat A, Yolas C, Aydin MD, Ezirmik N, Gundogdu C. First report of important causal relationship between the Adamkiewicz artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: An experimental study using a rabbit model.Asian J Neurosurg 2017;12:22-27


How to cite this URL:
Turkmenoglu ON, Kanat A, Yolas C, Aydin MD, Ezirmik N, Gundogdu C. First report of important causal relationship between the Adamkiewicz artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: An experimental study using a rabbit model. Asian J Neurosurg [serial online] 2017 [cited 2017 Mar 28 ];12:22-27
Available from: http://www.asianjns.org/article.asp?issn=1793-5482;year=2017;volume=12;issue=1;spage=22;epage=27;aulast=Turkmenoglu;type=0