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ORIGINAL ARTICLE
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Effect of radiation on brain tissue endothelin-1 level and tumor development


1 Department of Neurosurgery, Firat University, Elazig, Turkey
2 Department of Biochemistry, Firat University, Elazig, Turkey
3 Department of Radiation Oncology, Malatya, Inonu University, Turkey
4 Department of Neurology, Firat University, Elazig, Turkey

Correspondence Address:
Metin Kaplan,
Firat University, School of Medicine, Department of Neurosurgery, Elazig 23200
Turkey
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Source of Support: None, Conflict of Interest: None

Background: Radiotherapy causes injury in the endothelial cells of blood vessels and the production of vasoactive amines such as endothelin-1 (ET-1). ET-1 is an important peptide in cancer development. In this study, the effects of radiation on brain tissue ET-1 level were evaluated. Is it possible to suggest a mechanism using ET-1 level in the production of this adverse effect? In this paper, the relationship between the development of brain tumors and the ET-1 level has been discussed. Materials and Methods: Twenty-eight adult Sprague Dawley rats were used in the experiments. The rats were divided into four groups (n = 7) as follows: control group: radiation was not applied during the experiment; Group 1: Decapitated on the 1 st day following radiation; Group 2: Decapitated on the 7 th day following radiation; and Group 3: Decapitated on the 30 th day following radiation. ET-1 levels were measured with enzyme-linked immunosorbent assay (ELISA) method. The t-test, variance analysis, and Tukey honestly significant difference (HSD) tests were used in the statistical analysis. A value of P < 0.05 was accepted as significant. Results: No statistical differences were observed in the tissue ET-1 levels between the control group and other groups. According to the variance analysis and Tukey test, the differences between the groups were not significant. Conclusion: We observed in this study that the effects of radiation on brain tumor development or malignant transformation are not mediated by ET-1 levels. In addition, these results support the hypothesis of the fact that medical treatment with ET-1 antagonists in clinical cases receiving radiotheraphy is unnecessary.


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    -  Kaplan M
    -  Kilinc A
    -  Ozturk S
    -  Ilhan N
    -  Gurocak S
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