Brain metastases in cancer patients attending a Gamma Knife Center: A study from a single institute in Iran
Parisa Azimi1, Sohrab Shahzadi1, Mohammad Ali Bitaraf2, Maziar Azar2, Mazdak Alikhani3, Alireza Zali1, Sohrab Sadeghi1, Ali Montazeri4
1 Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Neurosurgery, Tehran University of Medical Science, Tehran, Iran
3 Department of Neurosurgeon, Iran Gamma Knife Center, Tehran, Iran
4 Mental Health Research Group, Health Metrics Research Centre, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran
Shohada Tajrish Hospital, Functional Neurosurgery Research Center of Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran
Source of Support: None, Conflict of Interest: None
Background: This study was aimed to explore data on brain metastases in cancer patients attending the Iranian Gamma Knife Center.
Meterials and Methods: This was a retrospective study. In all 5216 case records of patients who referred to the Iranian Gamma Knife Center for treatment of brain tumors during year 2003-2011 were reviewed. Data were explored to identify patients who developed brain metastases due to cancer and assessed the information as applied to cancer patients including survival analysis.
Results: Two hundred and twenty patients were identified as having brain metastases due to cancer. The mean age of patients was 54.0 (standard deviation [SD] =12.7) years. Patients were followed for an average of 7 months after treatment with gamma-knife. The median survival time for different the Graded Prognostic Assessment (GPA) was: GPA: 0-1, 4.0 ± 0.4 months; GPA: 1.5-2.5, 6.0 ± 0.7 months; GPA: 3, 9.0 ± 0.9 months; and GPA: 3.5-4.0, 12.0 ± 1.8 months and the overall median survival was 7.0 (SD = 0.6) months.
Conclusion: The findings suggest that many cancer patients in Iran might develop brain metastasis. Although, this is not a very high incidence compared with the existing statistics from other countries, there is an urgent need to explore the issue further.